The Cleveland Section of the American Chemical Society wishes to congratulate
Dennis J. Stuehr
Lerner Case Western Reserve University School of
Medicine and Lerner Research Institute of the
Cleveland Clinic Foundation
Winner of the 2018 Morley medal
The Morley address and medal will be presented on Wed. May 16 at the Michelson & Morley Restaurant on the campus of Case Western Reserve University. (details in May 2018 Isotopics and homepage)
2018 Morley Address:
"Some chemical and biological highlights of nitric oxide production by mammals"
That mammals might synthesize nitrogen oxides was first suspected in the late 1800’s, but remained controversial until experiments could finally be done using germ-free animals around 1980. While this early work was forging a clear tie between nitrogen oxide biosynthesis and stimulation of the mammalian immune system, parallel work was discovering a role for nitric oxide (NO) as a signal molecule for vascular relaxation in the mammalian circulatory system. These and related discoveries fueled a tremendous interest that led to the awarding of the 1998 Nobel prize in Physiology & Medicine for NO research, and the current publication of more that 6000 papers/year on NO biochemistry and biology. Mammals express three related NO synthase enzymes (NOSs) that each generate NO from the amino acid L-arginine under various biological settings and circumstances. Although NOSs are heme-containing enzymes whose catalysis is broadly similar to the cytochrome P450 enzymes, they have evolved separately and display some unique and interesting facets regarding their structure, reaction chemistry, cofactor use, and regulation. The Morley talk will highlight these unique aspects, and will specifically address how NOS enzymes catalyze an odd-electron chemistry to generate NO as their free radical product, and the “tricks” that NOS enzymes use to insure that their catalysis can go on, despite it generating a potent heme poison (NO) as a product.
Click here for a brief bio of Dr. Stuehr
About the Morley Medal :
The Cleveland Section annually sponsors a regional award, which consists of the Morley Medal and an honorarium of $2,000. The next presentation of the Morley Medal will take place at the meeting of the Cleveland Section ACS in May 2017. The award is presented at a banquet, at which time the recipient will deliver the Edward W. Morley Lecture for that year. Travel expenses for the medalist and spouse will be provided.
The purpose of the award is to recognize significant contributions to chemistry through achievements in research, teaching, engineering, research administration and public service, outstanding service to humanity, or to industrial progress.
The area of eligibility includes those parts of the United States and Canada within about 250 miles of Cleveland. The contributions for which the award is given should have been made by the awardee when a resident of this area, or if a major contribution was made elsewhere, the nominee should have continued to make contributions while a resident of this area. Nominations may be made by any member of the American Chemical Society, The Chemical Society or the Chemical Institute of Canada.